SUMMARY This article is directed to the University undergraduate or biology teacher who is already familiar with cellular physiology. The main purpose of this paper is to demonstrate the unlikelihood of evolution philosophy which claims that mutations can be beneficial in some cases and that the long-term accumulation of beneficial mutations can advance an organism to a more complex form — for example, an eye-less trilobite to one which can see. It will be shown that mutations lead to both a deterioration of the organism and a reduction in the adaptive potential of the species to future environmental changes. This would be more compatible with a creation philosophy of initially created complex life forms subsequently affected by deteriorative processes. Thus the article surveys what mutations are, and their effects on cellular metabolism. Natural selection is defined and its effect on mutational change in living organisms is briefly described. Other factors relating to the effects of mutations on cellular metabolism are also discussed. EN Tech. J., vol. 2, 1986, pp. 17–52
While this is an antiquated article it does give examples of the harmful effects of mutations in the major cellular metabolic pathways: DNA replication synthesis, protein synthesis and carbohydrate syntheses. Many more examples much more detailed are now available but this is still a valid reference. JGL Thank You to CMI for maintaining it on their site.
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